Key Topics

Derivation of No Significant Risk Levels for Three Lower Acrylates: Conclusions and Recommendations from an Expert Panel

California OEHHA Issues Notice to List Chemicals by the Labor Code Mechanism

REACH

BAMM Statement Regarding the Recent IARC Cancer Classifications for Three Acrylates (July 9, 2018)

IARC Advisory Group Prioritizes Ethyl Acrylate for Review

BAMM Submits Nomination of Ethyl Acrylate for Future IARC Monographs

IARC Has Acknowledged that the Cancer Classification for Ethyl Acrylate Warrants Reevaluation

NTP Delisted Ethyl Acrylate as a Carcinogen in 2000

The Michigan Department of Environmental Quality Discontinued Regulating Ethyl Acrylate as a Carcinogen in 2008

Health Canada Determined That Forestomach Tumors Observed in Rodents Do Not Justify Listing Ethyl Acrylate as CEPA-Toxic in 2010

The European Union Consumer Products Safety & Quality Unit Does Not Recognize Ethyl Acrylate as a Possible Human Carcinogen 

The Presidential/Congressional Commission on Risk Assessment and Risk Management  Identified Forestomach Tumors As Not Relevant to Humans, Citing Ethyl Acrylate as an Example 

Encyclopedia of Toxicology Updates for Methyl Acrylate, Ethyl Acrylate and n-Butyl Acrylate

Cancer weight of evidence for three lower acrylates: Conclusions and recommendations from an expert panel

Comprehensive Analysis of Chronic Rodent Inhalation Toxicity Studies for Methyl Acrylate

Murine Skin Carcinogenesis and the Role of Immune System Dysregulation in the Tumorigenicity of 2-Ethylhexyl Acrylate

Characterization Of Mode And Mechanism Of Action Data Related To Ethyl Acrylate-induced Rodent Forestomach Tumors And Their Relevance To Humans.” and “Evaluation Of The Scope Of Alkyl Acrylate Monoester Toxicology Data And Their Relevance To Chronic Human Health Adverse Outcome Assessments. Presented Platform
Presentation at SOT (March 11-15, 2018).

The role of ethyl acrylate induced GSH depletion in the rodent forestomach and its impact on MTD and in vivo genotoxicity in developing an adverse outcome pathway (AOP). 
Regulatory Toxicology and Pharmacology, February 2018.

A review of the genotoxic, mutagenic, and carcinogenic potentials of several lower acrylates. 
Toxicology, June 2018.

An Adverse Outcome Pathway (AOP) for forestomach tumors induced by non-genotoxic initiating events. 
Regulatory Toxicology and Pharmacology, July 2018.

Assessment of the mode of action underlying development to forestomach tumors in rodents following oral exposure to ethyl acrylate and relevance to humans. 
Regulatory Toxicology and Pharmacology, July 2018.

Critical Evaluation of 2-Ethylhexyl Acrylate Dermal Carcinogenicity Studies Using Contemporary Criteria. 
Toxicology Letters, September 2018.

Genotoxicity of methyl acrylate and ethyl acrylate and its relationship with glutathione

Ethyl Acrylate (EA) exposure and thyroid carcinogenicity in rats and mice with relevance to human health

In Vitro Genotoxicity Studies: n-Butyl Acrylate L5178Y Mouse Lymphoma (TK+/- Locus Assay and 2-Ethylhexyl Acrylate Gene Mutation Assay in Chinese Hamster V79 Cells. 
Toxicology Letters, October 2018.

BAMM's Position on Use of Acrylates in Artificial Nail Products

Safe Handling Manuals